Baik, L. S. & Carlson, J. R. The mosquito taste system and disease control. Proc. Natl Acad. Sci. USA 117, 32848–32856 (2020).
Ryan, S. J., Carlson, C. J., Mordecai, E. A. & Johnson, L. R. Global expansion and redistribution of Aedes-borne virus transmission risk with climate change. PLoS Negl. Trop. Dis. 13, e0007213 (2019).
Yang, B. et al. Modelling distributions of Aedes aegypti and Aedes albopictus using climate, host density and interspecies competition. PLoS Negl. Trop. Dis. 15, e0009063 (2021).
Coutinho-Abreu, I. V., Riffell, J. A. & Akbari, O. S. Human attractive cues and mosquito host-seeking behavior. Trends Parasitol. 38, 246–264 (2022).
Syed, Z. & Leal, W. S. Acute olfactory response of Culex mosquitoes to a human- and bird-derived attractant. Proc. Natl Acad. Sci. USA 106, 18803–18808 (2009).
Greppi, C. et al. Mosquito heat seeking is driven by an ancestral cooling receptor. Science 367, 681–684 (2020).
Laursen, W. J. et al. Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites. Neuron 111, 874–887.e878 (2023).
De Obaldia, M. E. et al. Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels. Cell 185, 4099–4116.e4013 (2022).
Corfas, R. A. & Vosshall, L. B. The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures. eLife 4, e11750 (2015).
Alonso San Alberto, D. et al. The olfactory gating of visual preferences to human skin and visible spectra in mosquitoes. Nat. Commun. 13, 555 (2022).
Zhao, Z. et al. Mosquito brains encode unique features of human odour to drive host seeking. Nature 605, 706–712 (2022).
McBride, C. S. et al. Evolution of mosquito preference for humans linked to an odorant receptor. Nature 515, 222–227 (2014).
McMeniman, C. J., Corfas, R. A., Matthews, B. J., Ritchie, S. A. & Vosshall, L. B. Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans. Cell 156, 1060–1071 (2014).
Vinauger, C. et al. Visual-olfactory integration in the human disease vector mosquito Aedes aegypti. Curr. Biol. 29, 2509–2516.e2505 (2019).
Lahondere, C. et al. The olfactory basis of orchid pollination by mosquitoes. Proc. Natl Acad. Sci. USA 117, 708–716 (2020).
Joseph, R. M. & Carlson, J. R. Drosophila chemoreceptors: A molecular interface between the chemical world and the brain. Trends Genet. 31, 683–695 (2015).
Weiss, L. A., Dahanukar, A., Kwon, J. Y., Banerjee, D. & Carlson, J. R. The molecular and cellular basis of bitter taste in Drosophila. Neuron 69, 258–272 (2011).
Lacaille, F. et al. An inhibitory sex pheromone tastes bitter for Drosophila males. PLoS ONE 2, e661 (2007).
Dweck, H. K. M. & Carlson, J. R. Diverse mechanisms of taste coding in Drosophila. Sci. Adv. 9, eadj7032 (2023).
Mustard, J. A. Neuroactive nectar: compounds in nectar that interact with neurons. Arthropod Plant Interact. 14, 151–159 (2020).
Afify, A. & Galizia, C. G. Chemosensory cues for mosquito oviposition site selection. J. Med. Entomol. 52, 120–130 (2015).
Matthews, B. J., Younger, M. A. & Vosshall, L. B. The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti. eLife 8, e43963 (2019).
Delgado-Povedano, M. M., Calderon-Santiago, M., Priego-Capote, F., & Luque de Castro, M. D. Study of sample preparation for quantitative analysis of amino acids in human sweat by liquid chromatography–tandem mass spectrometry. Talanta 146, 310–317 (2016).
Baker, L. B. & Wolfe, A. S. Physiological mechanisms determining eccrine sweat composition. Eur. J. Appl. Physiol. 120, 719–752 (2020).
Costa-da-Silva, A. L. Artificial membrane feeding mosquitoes in the laboratory with Glytube. Cold Spring Harb. Protoc. 2023, 108013 (2023).
Dunstan, R. H. et al. Sweat facilitated amino acid losses in male athletes during exercise at 32–34 degrees C. PLoS ONE 11, e0167844 (2016).
Baker, L. B. Sweating rate and sweat sodium concentration in athletes: a review of methodology and intra/interindividual variability. Sports Med 47, 111–128 (2017).
Attardo, G. M., Hansen, I. A., Shiao, S. H. & Raikhel, A. S. Identification of two cationic amino acid transporters required for nutritional signaling during mosquito reproduction. J. Exp. Biol. 209, 3071–3078 (2006).
Xiao, S., Baik, L. S., Shang, X. & Carlson, J. R. Meeting a threat of the Anthropocene: taste avoidance of metal ions by Drosophila. Proc. Natl Acad. Sci. USA 119, e2204238119 (2022).
Hol, F. J., Lambrechts, L. & Prakash, M. BiteOscope, an open platform to study mosquito biting behavior. eLife 9, e56829 (2020).
Murray, G. P. D., Giraud, E. & Hol, F. J. H. Characterizing mosquito biting behavior using the BiteOscope. Cold Spring Harb. Protoc. 2023, 108176 (2023).
Wood, C. S., Harrison, G. A., Dore, C. & Weiner, J. S. Selective feeding of Anopheles gambiae according to ABO blood group status. Nature 239, 165 (1972).
Giraldo, D. et al. Human scent guides mosquito thermotaxis and host selection under naturalistic conditions. Curr. Biol. 33, 2367–2382 e2367 (2023).
Chen, Y. D. & Dahanukar, A. Recent advances in the genetic basis of taste detection in Drosophila. Cell. Mol. Life Sci. 77, 1087–1101 (2020).
Matthews, B. J., McBride, C. S., DeGennaro, M., Despo, O. & Vosshall, L. B. The neurotranscriptome of the Aedes aegypti mosquito. BMC Genomics 17, 32 (2016).
Boyle, J. H. et al. A linkage-based genome assembly for the mosquito Aedes albopictus and identification of chromosomal regions affecting diapause. Insects 12, 167 (2021).
Wang, W. et al. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii. eLife 11, e81703 (2022).
Sanchez-Alcaniz, J. A. et al. An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing. Nat. Commun. 9, 4252 (2018).
Ganguly, A. et al. A molecular and cellular context-dependent role for Ir76b in detection of amino acid taste. Cell Rep. 18, 737–750 (2017).
Croset, V., Schleyer, M., Arguello, J. R., Gerber, B. & Benton, R. A molecular and neuronal basis for amino acid sensing in the Drosophila larva. Sci Rep. 6, 34871 (2016).
Jiao, Y., Moon, S. J., Wang, X., Ren, Q. & Montell, C. Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr. Biol. 18, 1797–1801 (2008).
Dahanukar, A., Lei, Y. T., Kwon, J. Y. & Carlson, J. R. Two Gr genes underlie sugar reception in Drosophila. Neuron 56, 503–516 (2007).
Aryal, B., Dhakal, S., Shrestha, B. & Lee, Y. Molecular and neuronal mechanisms for amino acid taste perception in the Drosophila labellum. Curr. Biol. 32, 1376–1386.e1374 (2022).
Jove, V. et al. Sensory discrimination of blood and floral nectar by Aedes aegypti mosquitoes. Neuron 108, 1163–1180.e1112 (2020).
Hussain, A. et al. Ionotropic chemosensory receptors mediate the taste and smell of polyamines. PLoS Biol. 14, e1002454 (2016).
Min, S., Ai, M., Shin, S. A. & Suh, G. S. Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila. Proc. Natl Acad. Sci. USA 110, E1321–E1329 (2013).
Rimal, S. et al. Mechanism of acetic acid gustatory repulsion in Drosophila. Cell Rep. 26, 1432–1442.e1434 (2019).
Montell, C. Drosophila sensory receptors-a set of molecular Swiss Army knives. Genetics 217, 1–34 (2021).
Melo, N. et al. The irritant receptor TRPA1 mediates the mosquito repellent effect of catnip. Curr. Biol. 31, 1988–1994.e1985 (2021).
Leung, N. Y. & Montell, C. Unconventional roles of opsins. Annu. Rev. Cell Dev. Biol. 33, 241–264 (2017).
Kwon, H. W., Lu, T., Rutzler, M. & Zwiebel, L. J. Olfactory responses in a gustatory organ of the malaria vector mosquito Anopheles gambiae. Proc. Natl Acad. Sci. USA 103, 13526–13531 (2006).
Saveer, A. M., Pitts, R. J., Ferguson, S. T. & Zwiebel, L. J. Characterization of chemosensory responses on the labellum of the malaria vector mosquito, Anopheles coluzzii. Sci Rep. 8, 5656 (2018).
de Bruyne, M., Foster, K. & Carlson, J. R. Odor coding in the Drosophila antenna. Neuron 30, 537–552 (2001).
Hallem, E. A., Ho, M. G. & Carlson, J. R. The molecular basis of odor coding in the Drosophila antenna. Cell 117, 965–979 (2004).
Cao, L. H. et al. Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila. Nat. Commun. 8, 1357 (2017).
Kessler, S., Vlimant, M. & Guerin, P. M. The sugar meal of the African malaria mosquito Anopheles gambiae and how deterrent compounds interfere with it: a behavioural and neurophysiological study. J. Exp. Biol. 216, 1292–1306 (2013).
French, A. S. et al. Dual mechanism for bitter avoidance in Drosophila. J. Neurosci. 35, 3990–4004 (2015).
Su, C. Y., Menuz, K., Reisert, J. & Carlson, J. R. Non-synaptic inhibition between grouped neurons in an olfactory circuit. Nature 492, 66–71 (2012).
Su, C. Y., Martelli, C., Emonet, T. & Carlson, J. R. Temporal coding of odor mixtures in an olfactory receptor neuron. Proc. Natl Acad. Sci. USA 108, 5075–5080 (2011).
Bonizzoni, M., Gasperi, G., Chen, X. & James, A. A. The invasive mosquito species Aedes albopictus: current knowledge and future perspectives. Trends Parasitol. 29, 460–468 (2013).
Lauer, J. et al. Multi-animal pose estimation, identification and tracking with DeepLabCut. Nat. Methods 19, 496–504 (2022).
Gonzalez, P. V., Gonzalez, Audino, P. A. & Masuh, H. M. Oviposition behavior in Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in response to the presence of heterospecific and conspecific larvae. J. Med. Entomol. 53, 268–272 (2016).
Yoshioka, M. et al. Diet and density dependent competition affect larval performance and oviposition site selection in the mosquito species Aedes albopictus (Diptera: Culicidae). Parasit. Vectors 5, 225 (2012).
Khan, Z., Bohman, B., Ignell, R. & Hill, S. R. Odour-mediated oviposition site selection in Aedes aegypti depends on aquatic stage and density. Parasit. Vectors 16, 264 (2023).
Jove, V., Venkataraman, K., Gabel, T. M. & Duvall, L. B. Feeding and quantifying animal-derived blood and artificial meals in Aedes aegypti mosquitoes. J. Vis. Exp. https://doi.org/10.3791/61835 (2020).
Matthews, B. J. et al. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature 563, 501–507 (2018).