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Common genetic variants contribute more to rare diseases than previously thought

Nature, Published online: 20 November 2024; doi:10.1038/d41586-024-03554-4 In rare diseases, rare mutations have long been thought of as the only

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Boston’s dense health-sciences networks help the city to maintain its lead

An analytical chemist works in the lab of biotech company Arcaea, which is based in Boston, Massachusetts.Credit: Boston Globe/Getty When

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How a fly’s behavioural state affects its view of the world

RESEARCH BRIEFINGS 20 November 2024 How animals adjust their visual attention as goals or environmental conditions change is unknown. In

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Squid-inspired jet devices deliver drugs without a need for needles

RESEARCH BRIEFINGS 20 November 2024 Microjet delivery systems that are inspired by cephalopods’ propulsion methods enable the needle-free administration of

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Trion sensing of a zero-field composite Fermi liquid

Willett, R. et al. Observation of an even-denominator quantum number in the fractional quantum Hall effect. Phys. Rev. Lett. 59,

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Spatially restricted immune and microbiota-driven adaptation of the gut

Parikh, K. et al. Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature 567, 49–55 (2019). Article  ADS 

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Early-twentieth-century cold bias in ocean surface temperature observations

Global mean temperature reconstruction method To predict global temperature metrics from the LSAT or SST records with incomplete coverage, we

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Normal breast tissues harbour rare populations of aneuploid epithelial cells

Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486, 346–352 (2012).

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Fibular reduction and the evolution of theropod locomotion

Hampé, A. Le développement du péroné dans les experiences sur la régulation des déficiences et des excédents dans la patte

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Exaptation of ancestral cell-identity networks enables C4 photosynthesis

Plant growth For the de-etiolation time course, seeds of Oryza sativa spp. japonica cultivar Kitaake and Sorghum bicolor BTx623 were