In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution
Selection of target genes and sgRNA design Five hundred sgRNAs were selected as initial targeting library. Fifty out of the
A eukaryotic-like ubiquitination system in bacterial antiviral defence
Oh, E., Akopian, D. & Rape, M. Principles of ubiquitin-dependent signaling. Annu. Rev. Cell Dev. Biol. 34, 137–162 (2018). Article
Tubulin code eraser CCP5 binds branch glutamates by substrate deformation
Roll-Mecak, A. The tubulin code in microtubule dynamics and information encoding. Dev. Cell 54, 7–20 (2020). Article CAS PubMed PubMed
Psilocybin desynchronizes the human brain | Nature
Regulatory approvals and registrations Written informed consent was obtained from all participants in accordance with the Declaration of Helsinki and
Sources of gene expression variation in a globally diverse human cohort
Mapping eQTLs and sQTLs at high resolution MAGE offers a valuable resource for uncovering the genetic factors that drive variation
A hot-Jupiter progenitor on a super-eccentric retrograde orbit
TESS photometry TIC 241249530 was observed with TESS9 from 24 December 2019 to 21 January 2020 (Sector 20) at a 30-min
Mechanical release of homogenous proteins from supramolecular gels
All chemicals were purchased from Sigma-Aldrich and used as received. Deionized water was used throughout. The gelator used here was
Adaptation to photoperiod via dynamic neurotransmitter segregation
Walton, J. C., Weil, Z. M. & Nelson, R. J. Influence of photoperiod on hormones, behavior, and immune function. Front.
Thresholds for adding degraded tropical forest to the conservation estate
All data manipulation, data analysis and construction of figures were conducted in the R v.4.02 computing environment46, using the packages
Threading the needle
I hear my office door open — a millisecond of sound — and look up for the thousandth time. But