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Childhood leukaemia in Down’s syndrome primed by blood-cell bias

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-02785-9 An in-depth investigation of gene regulation and cell populations at sites of fetal

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How your brain detects patterns in the everyday: without conscious thought

Neurons in the hippocampus (pictured) help to pick out patterns in the flood of information pouring through the brain.Credit: Arthur

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Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Samples from paediatric patients with ALL and HDs The current study is a secondary investigation using patient samples collected from

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Microbial iron limitation in the ocean’s twilight zone

Arrigo, K. R. Marine microorganisms and global nutrient cycles. Nature 437, 349–355 (2005). Article  ADS  CAS  PubMed  Google Scholar  Moore,

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Structural basis of archaeal FttA-dependent transcription termination

Sanders, T. et al. FttA is a CPSF73 homologue that terminates transcription in Archaea. Nat. Microbiol. 5, 545–553 (2020). Article 

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AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases

Zhang, D. et al. Metabolic regulation of gene expression by histone lactylation. Nature 574, 575–580 (2019). Article  ADS  CAS  PubMed 

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Jet stream controls on European climate and agriculture since 1300 ce

Stendel, M., Francis, J., White, R., Williams, P. D. & Woollings, T. in Climate Change 3rd edn (ed. Letcher, T.

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Human hippocampal and entorhinal neurons encode the temporal structure of experience

Participants The participants were 17 patients with intractable epilepsy who were implanted with depth electrodes to delineate a potentially surgically

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Larger and more instructable language models become less reliable

Figure 2 shows the results of a selection of models in the GPT and LLaMA families, increasingly scaled up, with

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The genetic architecture of protein stability

Combinatorial mutagenesis library designs Combinatorial library 1 Library 1 was designed using a computationally efficient greedy strategy to search for