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1993: A major genetic risk factor for late-onset Alzheimer’s disease
Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02885-6 The APOE gene, which codes for a fat-binding protein in the brain, is
1985: Disentangling tau pathology
Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02883-8 The protein tau is identified as the core component of neurofibrillary tangles —
‘It will be in the textbooks’
Credit: Dominick Reuter/AFP via Getty For a little more than a century, chemists have believed that strong atomic links called
Drugs like Ozempic seem to help everything from Alzheimer’s to infertility. But how?
Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. Bodies
Noble Nori: Elevating the Sushi Experience in Monticello, NY
Noble Nori is a premier destination for sushi lovers seeking both traditional Japanese flavors and modern culinary innovation. Known for
Phages reconstitute NAD+ to counter bacterial immunity
Millman, A. et al. An expanded arsenal of immune systems that protect bacteria from phages. Cell Host Microbe 30, 1556–1569
Mechanical forces as a signal in embryonic self-organization
RESEARCH BRIEFINGS 25 September 2024 A developing embryo is shaped by forces that are generated by the active contraction of
Nitrogen-doped amorphous monolayer carbon | Nature
Novoselov, K. S. et al. Electric field effect in atomically thin carbon films. Science 306, 666 (2004). Article ADS CAS
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Animals Six- to eight-week-old female CD45.2+Thy1.2+ C57BL/6 (C57BL/6J) mice, CD45.1+ mice (B6.SJL-Ptprca Pepcb/BoyCrl) and NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were purchased
Jekyll and Hyde flip of the script when bacteria invert gene sequences
Random mutation is a powerful approach used by many organisms, including bacteria, to generate genomic changes that can lead to