Department of Pathology, St Jude Children’s Research Hospital, Memphis, TN, USA
Petri Pölönen, Danika Di Giacomo, Abdelrahman Elsayed, Shunsuke Kimura, Francesca Benini, Lindsey E. Montefiori, Ilaria Iacobucci, Yunchao Chang, Yaqi Zhao, Pankaj S. Ghate & Charles G. Mullighan
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Danika Di Giacomo
Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN, USA
Anna Eames Seffernick, Abdelrahman Elsayed & Stanley B. Pounds
Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy
Francesca Benini
Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Research Hospital, Rome, Italy
Francesca Benini
Children’s Hospital Los Angeles, Laboratory Medicine, Los Angeles, CA, USA
Brent L. Wood
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Jason Xu, Jonathan Sussman, Caroline Diorio, David Frank, Kathrin M. Bernt, Stephen P. Hunger, Kai Tan & David T. Teachey
Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Changya Chen, Elizabeth Li, Caroline Diorio, Lahari Uppuluri, Alexander Li, Kathrin M. Bernt, Tiffaney L. Vincent, Stephen P. Hunger, Kai Tan & David T. Teachey
Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Changya Chen
Center for Applied Bioinformatics, St Jude Children’s Research Hospital, Memphis, TN, USA
Zhongshan Cheng, Jason Myers, Dale Hedges, Yawei Hui, Yiping Fan, Evadnie Rampersaud, Ti-Cheng Chang & Gang Wu
Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Haley Newman, Caroline Diorio, Rawan Shraim, Kathrin M. Bernt, Stephen P. Hunger & David T. Teachey
Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA
Soheil Meshinchi & Rhonda Ries
Global Pediatric Medicine, St Jude Children’s Research Hospital, Memphis, TN, USA
Meenakshi Devidas
Research Institute and Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, MN, USA
Stuart S. Winter
Division of Oncology, University of Virginia Children’s Hospital, Charlottesville, VA, USA
Kimberly P. Dunsmore
Department of Oncology, St Jude Children’s Research Hospital, Memphis, TN, USA
Hiroto Inaba
Division of Pediatric Hematology Oncology, Department of Pediatrics, NYU Langone Health, New York, NY, USA
William L. Carroll & Elizabeth Raetz
Department of Pediatrics and Pathology, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA
William L. Carroll & Elizabeth Raetz
Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH, USA
Nilsa C. Ramirez
Department of Structural Biology, St Jude Children’s Research Hospital, Memphis, TN, USA
Aaron H. Phillips & Richard W. Kriwacki
Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA
Richard W. Kriwacki
Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, TN, USA
Jun J. Yang
Department of Computational Biology, St Jude Children’s Research Hospital, Memphis, TN, USA
Jian Wang, Colleen Reilly & Xin Zhou
Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Mathijs A. Sanders
Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK
Mathijs A. Sanders
Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan
Junko Takita
Department of Pediatrics, Tokyo University, Tokyo, Japan
Motohiro Kato & Nao Takasugi
Department of Pediatrics, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA
Bill H. Chang
Department of Pathology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA
Richard D. Press
Department of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, University of Washington, Seattle, WA, USA
Mignon Loh
Center for Single Cell Biology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Kai Tan
M.L., E. Raetz, S.P.H., J.J.Y., M.D., H.I., S.W., K.D., W.L.C., N.C.R., K.B., C.D., L.U., D.F., S.M., R.R., A.L., T.L.V., P.S.G., M.A.S., J.T., M.K., N.T., B.H.C., R.D.P. and Y.Z. provided patient samples and collected data. P.P., Z.C., J.M., Y.H., Y.F., D.H. and E. Rampersaud preprocessed data. P.P., T.-C.C., G.W., H.N. and R.S. analysed genomic data. P.P., A.E.S., A.E. and S.B.P. performed statistical analyses. P.P., J.X., C.C., E.L., J.S., A.L. and K.T. analysed scRNA data. P.P., J.W., C.R. and X.Z. generated cloud-based visualizations. R.R., S.M. and T.V. isolated DNA and RNA. J.X. and C.C. performed single cell library preparation and sequencing. D.D.G. and L.E.M. performed HiChIP and ATAC–seq. R.D.P. performed targeted amplicon sequencing. F.B. and S.K. performed long-read sequencing. S.K. engineered MED12 KO cells, Y.C. performed western blotting. F.B., I.I. and S.K. performed luciferase report assays. B.L.W. analysed flow cytometry data. A.H.P. and R.W.K. analyzed AlphaFold2 models. P.P., C.G.M. and D.T.T. designed the study and wrote the manuscript.
