Categories: NATURE

How a bacterial immune system gets taken apart


  • RESEARCH BRIEFINGS

Investigating small protein inhibitors of CRISPR–Cas — an adaptive immune system in bacteria — has led to the discovery of a mechanism for inhibiting a large macromolecular complex. AcrIF25, an anti-CRISPR protein, blocks CRISPR–Cas activity by sequentially extracting all six Cas7 subunits from this complex.



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