Categories: NATURE

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria


  • Spinelli, J. B. & Haigis, M. C. The multifaceted contributions of mitochondria to cellular metabolism. Nat. Cell Biol. 20, 745–754 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Quintana-Cabrera, R. & Scorrano, L. Determinants and outcomes of mitochondrial dynamics. Mol. Cell 83, 857–876 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schworer, S. et al. Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. EMBO J. 39, e103334 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Arnold, P. K. et al. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature 603, 477–481 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Linder, S. J. et al. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells. Nat. Metab. 5, 2131–2147 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhu, J. et al. Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science 372, 968–972 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pilley, S. E. et al. Loss of attachment promotes proline accumulation and excretion in cancer cells. Sci. Adv. 9, eadh2023 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee, M. S. et al. Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature 616, 339–347 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gohil, V. M. et al. Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat. Biotechnol. 28, 249–255 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cai, X. et al. Lactate activates the mitochondrial electron transport chain independently of its metabolism. Mol. Cell 83, 3904–3920 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Titov, D. V. et al. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science 352, 231–235 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang, Z. et al. Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration. Cell Death Differ. 28, 303–319 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang, B. et al. The proline synthesis enzyme P5CS forms cytoophidia in Drosophila. J. Genet. Genomics 47, 131–143 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhong, J. et al. Structural basis of dynamic P5CS filaments. eLife 11, e76107 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, W. W., Freinkman, E., Wang, T., Birsoy, K. & Sabatini, D. M. Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. Cell 166, 1324–1337 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Edwards-Hicks, J. et al. MYC sensitises cells to apoptosis by driving energetic demand. Nat. Commun. 13, 4674 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fischer-Zirnsak, B. et al. Recurrent de novo mutations affecting residue Arg138 of pyrroline-5-carboxylate synthase cause a progeroid form of autosomal-dominant cutis laxa. Am. J. Hum. Genet. 97, 483–492 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kamphorst, J. J. et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 75, 544–553 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bartman, C. R. et al. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature 614, 349–357 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Collins, T. J., Berridge, M. J., Lipp, P. & Bootman, M. D. Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J. 21, 1616–1627 (2002).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benador, I. Y. et al. Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion. Cell Metab. 27, 869–885 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Han, M. et al. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature 615, 712–719 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carraro, M. et al. The unique cysteine of F-ATP synthase OSCP subunit participates in modulation of the permeability transition pore. Cell Rep. 32, 108095 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Branon, T. C. et al. Efficient proximity labeling in living cells and organisms with TurboID. Nat. Biotechnol. 36, 880–887 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luengo, A. et al. Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Mol. Cell 81, 691–707 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stephan, T. et al. MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation. EMBO J. 39, e104105 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Quintana-Cabrera, R. et al. The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function. Nat. Commun. 9, 3399 (2018).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cogliati, S. et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell 155, 160–171 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Detmer, S. A. & Chan, D. C. Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. J. Cell Biol. 176, 405–414 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giacomello, M., Pyakurel, A., Glytsou, C. & Scorrano, L. The cell biology of mitochondrial membrane dynamics. Nat. Rev. Mol. Cell Biol. 21, 204–224 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yao, C.-H. et al. Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation. eLife 8, e41351 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yasuda, T., Ishihara, T., Ichimura, A. & Ishihara, N. Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways. Cell Rep. 42, 112434 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hsu, K.-S. et al. Cancer cell survival depends on collagen uptake into tumor-associated stroma. Nat. Commun. 13, 7078 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kleele, T. et al. Distinct fission signatures predict mitochondrial degradation or biogenesis. Nature 593, 435–439 (2021).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Rath, S. et al. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 49, D1541–D1547 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727–730 (2001).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Osellame, L. D. et al. Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. J. Cell Sci. 129, 2170–2181 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Korobova, F., Gauvin, T. J. & Higgs, H. N. A role for myosin II in mammalian mitochondrial fission. Curr. Biol. 24, 409–414 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Adams, K. J. et al. Skyline for small molecules: a unifying software package for quantitative metabolomics. J. Proteome Res. 19, 1447–1458 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Heinrich, P. et al. Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR. Sci. Rep. 8, 17910 (2018).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, W. W., Freinkman, E. & Sabatini, D. M. Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites. Nat. Protoc. 12, 2215–2231 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cho, K. F. et al. Proximity labeling in mammalian cells with TurboID and split-TurboID. Nat. Protoc. 15, 3971–3999 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vander Heiden, M. G., Chandel, N. S., Williamson, E. K., Schumacker, P. T. & Thompson, C. B. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91, 627–637 (1997).

    Article 

    Google Scholar
     



  • Source link

    fromermedia@gmail.com

    Share
    Published by
    fromermedia@gmail.com

    Recent Posts

    How understudied endometriosis causes pain for hundreds of millions of women

    Many women live with endometriosis but scientists say research into the condition is underfunded.Credit: GARO/PHANIE/Science…

    13 hours ago

    Observation of vortices in a dipolar supersolid

    Gross, E. P. Unified theory of interacting bosons. Phys. Rev. 106, 161 (1957).Article  ADS  CAS …

    13 hours ago

    A broadband hyperspectral image sensor with high spatio-temporal resolution

    Landgrebe, D. Hyperspectral image data analysis. IEEE Signal Proc. Mag. 19, 17–28 (2002).Article  ADS  Google…

    13 hours ago

    The United Kingdom’s only Black chemistry professor, on diversity

    ChangemakersThis Nature Q&A series celebrates people who fight racism in science and who champion inclusion.…

    13 hours ago

    Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles

    Diering, G. H. et al. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science…

    13 hours ago

    Imaging shapes of atomic nuclei in high-energy nuclear collisions

    Accessing information in the intrinsic frameThe nuclear shape in the intrinsic frame is not directly…

    13 hours ago